Synthesis of Isoxazolyl-benzenesulfonamide derived from N -[4-(2,3-dibromo-3-aryl-propanoyl)-phenyl]benzenesulfonamide | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Synthesis of Isoxazolyl-benzenesulfonamide derived from N -[4-(2,3-dibromo-3-aryl-propanoyl)-phenyl]benzenesulfonamide

Author(s): Hemant S. Chandak

N-[4-(2,3-dibromo-3-aryl-propanoyl)-phenyl]benzenesulfonamide on reaction with hydroxylamine hydrochlorde in ethanol in presence of catalytic amount of piperidine afforded N-(4-(5-arylisoxazol-3- yl)phenyl)benzenesulfonamides. Under microwave irradiation, reaction proceeds smoothly in ethanol without using piperidine. The reaction time was 4-5 minutes and yields were better. The synthesized compounds are characterized by elemental analysis, IR, 1H NMR and Mass spectral data.


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