Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


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Synthesis of Naratriptan using new intermediate N-Benzyl-N-Methyl Ethenesulfonamide

Author(s): B Venugopala Rao, VSH Krishnana, K Venkateswara Rao, V Ravi Sankar and PK Dubey

A novel intermediate N-benzyl-N-methylethenesulfonamide (3) synthesis has been reported. This on reaction with 5-bromo-3-(1-methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole (4) under heack condition gave N-benzyl-N-methyl-2-[3-(1-methyl-1, 2, 3, 6,-tetrahydro pyridine -4-yl)- 1H-indol-5-yl] ethene sulfonamide (5) . Later on 5 was subjected to the hydrogenation, followed by debenzylation to afford naratriptan (1) with high purity.


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