Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Synthesis of new 5-naphthyl substituted 1,3,4-oxadiazole derivatives and their antioxidant activity

Author(s): Priscilla Patrao, A. M. A. Khader, Balakrishna Kalluraya and Vinayachandra

A new series of 1-(substituted)-2-({5-[(naphthalen-1/2-yloxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)ethanone 5 was synthesized by reacting 5-[(naphthalen-1/2-yloxy)methyl]-1,3,4-oxadiazole-2-thiol 4 with appropriate α-haloketones by multistep organic synthesis. The newly synthesized compounds were characterised by IR, 1H NMR, mass spectral data and elemental analysis. They were evaluated for antioxidant properties. Few of them exhibited promising activities.


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