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Synthesis of new pyrazoline derivatives and their cytotoxic and antiinflammatory screening | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis of new pyrazoline derivatives and their cytotoxic and antiinflammatory screening

Author(s): Vani A, Gayatri B, Saisree K, Sikender M, Madhava Reddy B and Harinadha Babu V

Six new derivatives of pyrazoline incorporated imidazo(1,2-a)pyridines 6(a-f) were synthesized and evaluated against anti inflammatory and invitro anti cancer activities. Claisen- Schmidt condensation of 2-aryl imidazo( 1,2-a) carbaldehydes (4a&4b) with substituted acetophenones gave 2-aryl imidazo pyridinyl chalcones 5(a-f). Cyclization of 5(a-f) with hydrazine hydrate afforded 2-(4- substituted phenyl)-3-(3-(4- substituted phenyl)4,5-dihydro-1Hpyrazol- 5-yl)imidazo[1,2-a]pyridines 6(a-f) in good yields. The structures of the synthesized compounds were confirmed on the basis of physical and spectral data. In MTT assay,some of the compounds have shown superior activity against MCF-7 and Hela cell lines and moderate activity aganist DU-147 cell lines. In anti-inflammmatory screening, 6e exhibited significant activity while the other compounds were moderately active.


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