Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis of N-isopropylphenoxypropanolamine analogue and their electrocatalysis for the determination of dopamine: A cyclic voltammetric study

Author(s): M. T. Shreenivas, B. E. Kumara Swamy, J. G. Manjunatha, Umesh Chandra, S. Sharath Shankar, B. S. Sherigara

1-(p-tolyloxy)-3-chloropropan-2-ol (TCPL) was prepared as an analogue to the Nisopropylphenoxypropanolamine and it was characterized by LCMS, 1H NMR and purity by HPLC. The prepared compound was used as a modifier for the electrochemical determination of dopamine (DA). The effect of scan rate, concentration and pH was studied. The overall electrode process was found to be both adsorption and diffusion controlled. The effect of concentration and pH was studied. The detection limit of DA at the modified electrode was found to be 4.5 X 10 -7 M.Hence this electrode can be used for the selective and sensitive determination of DA.


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