Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Synthesis of novel 2-amino thiazole derivatives

Author(s): V. Deepti, M. Aruna Kumari, N. Harikrishna, G. Ramesh and C. Venkata Rao

Structurally diverse thiazoles were conveniently synthesised by one pot procedure by the reaction of α-haloketones and thioamides substituted with electron-donating and electron-withdrawing groups. The desired 2-aminothiazoles with alkyl or aryl or halo substitutions can be obtained in good yields. The effect of substitution was investigated. Their chemical structures were established by IR, 1H NMR, mass spectral studies and elemental analyses.


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