Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Synthesis of Novel 3-Aryl-isoxazolo[4,3-h]quinolines via Nucleophilic Substitution of Hydrogen (SNH)

Author(s): Latifa Bouissane, Najat Belkhouya, Adiba Rais, Ouafae Abdelaoui, Hakima Chicha, Assoman Kouakou and El Mostapha Rakib

A simple and efficient one-pot method for the synthesis of novel 3-aryl-isoxazolo[4,3-h]quinolines is described. The nucleophilic substitution of hydrogen is carried out by treating various arylacetonitriles with commercially available 8-nitroquinoline in basic methanol solution. The same synthetic approach has been used to obtain new isoxazolo[3,4-g]indazole and isoxazolophtalic anhydride.


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