Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Synthesis of Novel 4-Thiazolidinone Derivatives Incorporated with Benzothiazole and its Antimicrobial Activity

Author(s): Sambhaji. P. Vartale, Digambar. B. Kadam, and Nilesh. K. Halikar

A series of novel tetrazoloquinoline schiff’s bases 3a-g,4a-g,5a-g,6a-g,7a-g were prepared from 6/7/8-trisubstituted quinoline carbaldehyde . All tetrazolo quinoline Schiff bases were refluxed with thioacetic acid in presence of anhydrous zinc chloride and solvent N,N-dimethyl formamide to afforded novel series of 4-thiazolidinone 8a-g,9a-g,10a-g,11a-g,12a-g.All synthesized 4- thiazolidinone were screened for their antimicrobial activity.