Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Synthesis of Novel Azo Dyes Derived from 8-Hydroxyquinoline

Author(s): Rouda F, Bahloul A, Abourriche A, Kitane S

The novel azo dyes derived from the 7-substituted 8-Hydroxyquinoline (8HQ) presented in this work were synthesized by a coupling reaction with 8HQ derivatives using a primary aromatic amine. These new azo dyes were obtained with quantitative yields varying between 75 and 90% with a predominance of the trans-isomer. They may have potential biological properties compared to similar compounds. The structure of the new heterocyclic compounds obtained not yet described in the literature was confirmed on the basis of the 1H NMR (300MHz) and 13C NMR (75MHz) spectroscopic parameters.