A series of chlorine substituted 2-(3,5-dimethyl-pyrazol-1-yl)-6-fluoro-benzothiazoles were synthesized, by the reaction of 7-chloro-2-(3,5-dimethyl-pyrazol-1-yl)-6-fluoro-benzothiazole with various amines and alcohols in the presence of dimethyl formamide and anhydrous potassium carbonate, characterized by IR, NMR and elemental analysis. All the synthesized compounds were screened for their in vitro antibacterial activity against some Grampositive and Gram-negative bacteria. The antibacterial study revealed that compounds 6(a–k) have shown moderate activity against Gram-positive and Gram-negative organisms when compared with reference amoxicillin. Compound 6g, 6k and 6f were found to be more the most active against Gram-positive and Gram-negative bacteria.
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