Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Synthesis of novel indolyl-thiazolidinone derivatives as antioxidant, antimicrobial and atitubercular agents

Author(s): Prabhaker Walmik and Saundane A. R.

The present study envisaged the development of novel antioxidant, antimicrobial and antitubercular candidates using the indole scaffold. Several novel indole derivatives (3a-i) were prepared. The structures of these compounds were confirmed by their elemental analysis, IR, 1H NMR, 13C NMR and mass spectral data. All the synthesized compounds 3a-i were screened for their in vitro antioxidant activity by various methods such as 1,1-Diphenyl-2- picryl hydrazyl (DPPH) radical scavenging activity (RSA), Ferric ions (Fe3+) reducing antioxidant power (FRAP) and Ferric ions (Fe3+) reducing antioxidant power (FRAP) antimicrobial and antitubercular activities. In vitro antioxidant, antimicrobial and antitubercular activities Compounds 3a and 3c exhibited good RSA and FRAP at a concentration 100 μg/mL.Compounds 3a and 3c exhibited good metal chelating activity at a concentration 100 μg/mL. Compound 3a exhibited promising antitubercular activity MIC 3.125 μg/mL. Compound 3a exhibitted potent antimicrobial activity with MIC 125 μg/mL against K. pneumonia (NCTC-13368) and Aspergillus terreus (MTCC- 1782). Whereas, the compound 3a exhibited promising antitubrcular activity against mycobacterium tuberculosis (ATCC-2794) with MIC 3.125 μg/mL


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