Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Synthesis of Novel Isoxazoline Derivatives Containing s-Triazine via Chalcones and their Anti-Microbial Studies

Author(s): Ramkumar P Dongre, Shantilal D Rathod

In this series different Isoxazoline were prepared i.e., 4,6-diethoxy-N-(4-(4,5-dihydro-5-phenylisoxazol-3yl)phenyl)-1,3,5-triazin-2-amine 7(a-h) via cyclisation of chalcone intermediate. The structures of prepared compounds were confirmed by spectral analysis. The antibacterial and antifungal activities of the final products against various bacteria and fungi have also been reported. Most of the compound showed good to moderate activity.