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Synthesis of novel substituted quinazoline and quinazolin-4(3H)-one derivatives of expected antitumor activity | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis of novel substituted quinazoline and quinazolin-4(3H)-one derivatives of expected antitumor activity

Author(s): Ghaneya S. Hassan, Hanan H. Georgey, Nashwa A. Ibrahim, Shimaa S. Zaki

Series of 2,4-disubstituted quinazoline and 2-substituted or 2,3-disubstituted quinazolin-4(3H)-one derivatives as antitumor agents were designed and synthesized. The structures of the newly synthesized compounds were elucidated by IR, 1H NMR, 13C NMR, mass spectroscopy and elemental analyses. The antitumor activity of the target compounds were evaluated using the National Cancer Institute disease oriented antitumor screening protocol. It was found that all the tested compounds showed activity against two cell lines (CNS and renal) and compound 21 was the most active derivative in this study with GI% 59.44 against HOP-92.


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