Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Synthesis of oxcarbazepine by newer method

Author(s): Aziz-Ur-Rahman, Mohd Fareedullah, S. H. Rizwan

Epilepsy is one other most common ailment of man with a prevalence of approximately 1%. It is estimated that 50 millions person’s world wide may have this disorder. Although many are well controlled with available therapies, perhaps one quarter of the total continue to have seizures. Anticonvulsant drugs are the mainstay of epilepsy management and may have to be taken for life. In more than 20% of those affected, chronic in aractable (refraction) epilepsy develops. This necessitates the use of combination therapy. But the use of these drugs in combination is plagued by cognitive impairment and drug interactions with the results that only about 10% of the patients with refractory epilepsy seem to benefit substantially from polypharmacy. Thus the new viable antiepileptic molecules are urgently needed. In an effort to improve the tolerability profile of the carbamazepine without affecting its epileptic potency, the keto analogue oxcarbazepine was developed. Oxacarbazepine has developed its efficacy and its improved safety profile and is now considered as epileptic drug of first choice. Some of the synthetic routes of oxcarbazepine described in the literature used costlier raw materials and the reported yield is less. Hence, an attempt was made to synthesize oxcarbazepine by modified route that reduces the costly raw materials, cost of production with high yield.


PDF

FIND ARTICLES
SCImago Journal & Country Rank
 
Erkek öyle sert ve acımaz sikiyor ki bayan çaresiz bir şekilde tırtıl misali sikiş yataktan aşağı doğru kayıyor fakat hem adam hemde kadın aşırı mobil porno derecede zevk alıyorlar Uzun zamandır karısı ile ilgili planları olan türk porno adam onu başkaları sikerken hayal ediyor bu durumu karısından sikiş izle gizliyordu fakat bir gün adamın moralinin bozuk olduğunu anlayan karısı sikiş ona ne olduğunu sordu ve adamda ona her şeyi anlatmıştı karısı bu porno resim durumdan Büyük zenci yarağı sevenler için özel olarak eklenmiş videomuz türk porno kalın ve damarlı zenci siki arayıp bulamayanlar için özel olarak sikiş izle yayınlanmıştır filmde ise sarışın zengin sürtük büyük mobil sikiş kalın damarlı alet sevdiğini bir çok kez dile getirmiş