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Synthesis of Schiff bases as potent sa-fab1 inhibitors and antibacterial agents | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis of Schiff bases as potent sa-fab1 inhibitors and antibacterial agents

Author(s): Krist├â┬â├ć┬ĺ├â┬é├é┬Żna Labudov├â┬â├ć┬ĺ├â┬é├é┬í, Dhanya Sunil* and Pooja R. Kamath

Staphylococus aureusis a ubiquitous pathogen responsible for broadspectrum of human infections. Treatment is very limited due to its resistence to current antibiotics and there is an urgent need to develop new antibiotics which will be more effective. This study focuses on synthesis and characterization of two new series of schiff bases and determination of its antibacterial potential.Molecular docking studies of schiff base molecules were carried out using enoyl-ACP reductase crystal structure complexed with NADPH.Compounds 3dand 6bthat showed high docking score in in silico studies exhibited good antibacterial properties against S. aureus. The higher antibacterial activity and better docking properties reflects the potential of 3d and 6b as potential leads for developing antibacterial agents aginst S aureus.


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