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Synthesis of some 1,2,3-triazoles derivatives and evaluation of their antimicrobial activity | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis of some 1,2,3-triazoles derivatives and evaluation of their antimicrobial activity

Author(s): Ismail Fichtali, Marwa Chraibi, Fatima El Aroussi, Abdeslem Ben-Tama, El Mestafa El Hadrami, Kawtar Fikri Benbrahim and Salah-Eddine Stiriba

All 1,2,3-triazoles derivatives were synthesized via 1,3-dipolar CuAAC, while the derivative 14 was synthesized by Huisgen 1,3-dipolar cycloaddition reaction between dimethylacetylene dicarboxylate and N-protected methyl azido glycinate. All synthesized compounds structures were confirmed by spectral techniques 1H NMR, 13C NMR, and mass spectrometry (MS). The antimicrobial activity of these compounds was tested against two Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), four Gram-positive bacteria (Micrococcus luteus, Bacillus cereus, Bacillus subtilis and Staphylococcus aureus) and one fungal strain (Candida albicans). The compounds 14 showed an interesting inhibitory effect against all Gram-positive bacteria studied compared to the other derivatives


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