Synthesis of some arylidene derivatives of thiazolopyrimidineas anticancer | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Synthesis of some arylidene derivatives of thiazolopyrimidineas anticancer

Author(s): Tawfeek Ahmed Ali Yahyaa, Jalal H. Abdullaha, Mokhtar Abd Hafiz Al-Ghorafib and Shada H. Yassina and Hassan M. Almahbshic

A series of arylidenesarylidenes(D1-10) were synthesized by reaction of the thiazolopyrimidinones(C1&C2) with the appropriate aldehyde. The arylidene derivatives (D3) and (D8) showed significant anticancer activity (IC50= 4.32 and 4.72 μg/ml respectively) when compared to standard drug doxorubicin (IC50= 3.76 μg/ml).


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