Mannich bases of sulphadiazine, sulphamethoxazole, sulphacetamide with 2- amino -3 -methyl benzothiazole, 2 - amino chloro benzothiazole and 2 -amino 5 -chloro 6- fluro benzothiazole were synthesized. The structures of the various derivatives were characterized by various spectral data’s and by elemental analysis. The synthesized compounds were screened for their anti tubercular activity useing Lowenstein-Jensen (L.J) medium against Mycobacterium tuberculosis H37 RV strains and the anti microbial activity against bacteria i.e. Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa Klebsiella pneumoniae and fungi Candida albicans and Aspergillus niger . Compounds 6a, 6b, 6c and 6d were active against Mycobacterium tuberculosis H37 RV strains. The antimicrobial activity was evaluated by comparing the zone of inhibition of the tested compounds with the standard sulphamethaoxazole and Flucanazole. Very significant activity was exhibited from 6a, 6b, 6d and 6e against P aeruginosa, Significant activity was noted from 6a, 6d, 6e and 6h derivatives against Bacillus subtilis while 6a, 6b, 6d and 6e showed significant activity against E. coli. All other derivatives exhibited moderate activity against Bacillus subtilis and E. coli. However there was no activity against fungi.