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Synthesis of some new antimicrobial 5,6,7,8- tetrahydropyrimido[4,5-b]quinolone derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Synthesis of some new antimicrobial 5,6,7,8- tetrahydropyrimido[4,5-b]quinolone derivatives

Author(s): Maher A. El-Hashash, Sherif M. Sherif, Azza A. E. Badawy, Huda R. M. RashdanTetrahydroquinoline, Pyrimidoquinolines, Hydrazonoyl halides, Antimicrobial activity

2-Amino-1-aryl-1,4,5,6,7,8-hexahydro-4-phenylquinoline-3-carbonitrile derivatives were synthesized by the reaction of cyclohexanone (1) with 2-benzylidinemalononitrile (2) and the appropriate of aniline derivatives. The reactivity of some of these newly synthesized derivatives toward carbon disulfide and further toward hydrazonoyl halides were also studied. In addition, the antimicrobial activity of the newly synthesized derivatives was reported.


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