Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis of Some New Heterocyclic Compounds Derived from 2-Chlorobenzoic Acid as Potential Biological Activity
Author(s): Amagonda Loni*, Champa M, Yogesh Subhash PatilThe new series of 1,3,4-oxadiazole derivatives were synthesized by reaction between 2-chloro benzoic acid hydrazide with different acid cyclization by using phosphorous oxychloride the synthesized compound analyzing of mass, NMR and check biological activity the 1,3,4-oxadiazole have been reported to possess anti-inflammatory, anti-HIV, anti-bacterial, anti-convulsant activities, anti-malarial, herbicidal, anti-anxiety, insecticidal, anti-tubercular, anti-viral, anti-fungal, anti-HBV, anti-cancer, analgesic etc. This article discusses synthesis of 1,3,4-oxadiazole different derivatives and screening for biological activity against the antifungal drugs like ketoconazole, clotrimazole and anti-bacterial activity against ampicillin.
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