Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Synthesis of some new pyrrole derivatives and their antimicrobial activity

Author(s): A.Idhayadhulla, R. Surendra Kumar, A. Jamal Abdul Nasser and Aseer Manilal

A new pyrrole derivatives of 5,5'-(3,5-dimethyl-1H-pyrrole-2,4-diyl)bis(1,3,4-oxadiazole-2- thiol)(3), 5,5'-(3,5-dimethyl-1H-pyrrole-2,4-diyl)bis(4-amino-4H-1,2,4-triazole-3-thiol)(4), 5,5’- (3,5-dimethyl-1H-pyrrole-2,4-diyl)bis(4H-1,2,4-triazole-3-thiol) (6), and 5,5'-(3,5-dimethyl-1Hpyrrole- 2,4-diyl)bis(1,3,4-thiadiazol-2-amine)(7) were prepared from cyclization methods. Synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, mass spectral and elemental analysis. The reaction was performed by using ordinary condensation type, which enabled to easy work-up and good yield. Synthesized compounds (1-7) were screened for antimicrobial activity.


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