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Synthesis of some new substituted fluoro benzimidazoles and their antimicrobial screening | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis of some new substituted fluoro benzimidazoles and their antimicrobial screening

Author(s): B. Nandha, H. Kuntal, J. N. Narendra Sharath Chandra, L. V. G. Nargund, P. Rashmi, M. S. Harish and D. S. Puranik

A series of novel 5-fluoro-2-[(2'-(1-trityl tetrazol-5-yl) biphenyl-4-yl methyl) thio]-6-substituted-1H-benzimidazoles were prepared by alkylation of 6-substituted-2-mercapto-5-fluoro benzimidazoles with 5-[4'-(bromo methyl) biphenyl-2-yl]-1-trityl-1H-tetrazole. The synthesized compounds were screened against different strains of bacteria and fungi. The most active derivatives of the present series were the azole (imidazole and 1,2,4-triazole) substituted fluoro benzimidazoles and the para chloro phenyl ether analog indicating the importance of a halogenated diphenyl ether nucleus and the azole moiety at the 6th position. The results suggest that these three molecules are potential candidates for further development as antibacterial and antifungal agents.


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