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Synthesis of some novel Mannich bases bearing pyrazolone moiety | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Synthesis of some novel Mannich bases bearing pyrazolone moiety

Author(s): L. K. Ravinrdanath, B. V. Chakravarthi, S. Muralikrishna and S. Harikrishna

Synthesis of N1(2-OXO-1-(piperidine-yl methyl) indoline 3-ylidine )-2-(4-(5-oxo-4(2-phenyl hydrazono )-3-trichloro methyl )-4,5-di hydro -1-H pyrazol-1-yl) phenoxy) aceto hydrazono) were synthesis by condensation of 2-(4-(5-oxo- 4(2-phenyl hydrazono)-3-(trichloro methyl)-4,5,-di hydro-1-H pyrazol-1-yl) phenaxy )N-(2-oxoindoline)-3-ylidine) acetohydrazide with isatin offered corresponding ynthesis of N1(2-OXO-1-(piperidine-yl methyl) indoline 3-ylidine )-2-(4-(5-oxo-4(2-phenyl hydrazono )-3-trichloro methyl )-4,5-di hydro -1-H pyrazol-1-yl) phenoxy) aceto hydrazide) this was subjected manich reaction with cyclic secondary amines such as piparardine or morpholine or N-methyl piparazine in presence of formaldehyde in DMF to give corresponding manich base sysnthsis of N1-2oxo - 1-(4-substituted hydrazono)3-(trichloromethyl)-4,5,-dihydro-1H-pyrazol-1yl)phenoxo)acetohydrazide in excelent yield. The structurer of these newly synthesis compound were charactrised by H1-NMR,C13-NMR,Mass and IR elemental analysis


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