Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Synthesis of some novel pyrrolidine, thiomorpholine, pyrimidine and pyridine derivatives containing benzimidazole moiety of expected antiviral and antimicrobial activity

Author(s): Sadia A Hessein, Sawsan A Fouad, Reham R Raslan and Nadia A Shemiss

A series of new substituted pyrrole, thiomorpholine-3, 5-dione, pyrimidine, thiazole and pyrazole derivatives were synthesized from N-(4-(1H-benzo[d] imidazol-2-yl) phenyl-2-chloroacetamide (2) as starting material. Also, N (4- (1H-benzo[d]imidazol-2-yl) phenyl)-3-oxobutanamide (17) is widely used for production of pyridine and chromeno[3,4-c]pyridin-1-carboxamide derivatives. Most of the target compounds were evaluated for their antiviral and antimicrobial activities.


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