Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Synthesis of the heterocyclic chalconoid derivatives

Author(s): Chanti Babu Patneedi, Durga Prasadu K and R. S. K. Sharma

Chalconoids, also known as chalcones, they form the central core for a variety of important biological compounds. They show antibacterial, antifungal, antitumor and anti-inflammatory properties. Some chalconoids demo nstrated the ability to block voltage-dependent potassium ch annels [1]. Chalcones are also natural aromatize in hibitors [2]. Chalcones are starting compounds in synthesis of he terocycles containing di nitrogen atoms which named (di aze) ,an attempt to synthesis of chalcones from acetanil ide with aromatic aldehydes such as p-N,N-dimethyl Benzaldehyde and p-hydroxy benzaldehyde by Claisen- Schmidt condensation. The resulting chalcones afte r purification have been converted into substituted p yrazoline and pyrimidine by reaction with hydrazine hydrate, urea, thiourea and guanidine. All these compounds w ere characterized by Physical and spectral methods such as melting point, 1 H-NMR and C.H.N analysis.


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