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Synthesis, Reactions and Antimicrobial Activity of Some 10,10-dimethylchromeno[4',3':4,5]thieno[2,3-d]pyrimidin-4-ones | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis, Reactions and Antimicrobial Activity of Some 10,10-dimethylchromeno[4',3':4,5]thieno[2,3-d]pyrimidin-4-ones

Author(s): Hala EM Tolan, Ahmed H Shamroukh, Aymn E Rashad, Mohammed I Hegab

A variety of 10,10-dimethyl-3H,10H-chromeno[4',3':4,5]thieno[2,3-d]pyrimidin-4-ones (4a-c) were synthesized, in one pot reaction, via the reaction of 2-amino-4,4-dimethyl-4H-thieno[2,3-c]chromene-1-carbonitrile (3a,b) with various aliphatic acids in the existence of phosphorus oxychloride. Moreover, 8,8-dimethyl-8H-chromeno[4',3':4,5]thieno[3,2-e][1,3,4]triazolo[1,5-c]pyrimidines (7a-c) were prepared from the reaction of 4-hydrazino-10,10-dimethyl-10H-chromeno[4',3':4,5]thieno[2,3-d]pyrimidin-4-ones (6a-c) with benzoyl chloride. The newly synthesized chromeno[4',3':4,5]thieno[2,3-d]pyrimidin-4-ones derivatives were proved by their Infra-red (IR), Proton Nuclear Magnetic Resonance (1H-NMR), MS spectra and elemental analyses. The newly synthesized products (6a-c) and (7a-c) showed promising antimicrobial activity.


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