Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis, reactivity and antitumor activity of some new pyrazolo[3,4-d] pyrimidine and their triazole derivatives

Author(s): Ibrahim F. Nassar* and Samy A. El Assaly

Some pyrazolo [3, 4- d] pyrimidines derivatives and their triazole derivatives were synthesized starting from p-toluene sulfonyl hydrazide 1 by reaction with different electrophilic and nucleophilic reagents. Some of the newly synthesized compounds have been evaluated for their potential cytotoxicity against breast cancer cell line (MCF7), which show high activity.


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