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Synthesis, some reactions, cytotoxic evaluation and antioxidant study of novel benzimidazole derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis, some reactions, cytotoxic evaluation and antioxidant study of novel benzimidazole derivatives

Author(s): S. N. Abd el Al and F. M. A. Soliman

A series of novel benzimidazole derivatives incorporating chalcone (3), pyrazolines(4),(5), (16), oxazoline(6), pyrimidines(7-13),(17) and oxirane(15) derivatives were synthesized and some of their reactions with some electrophiles and /or nucleophiles were studied . Some of the new derivatives were biologically evaluated as antioxidants and the results showed that the presence of the epoxide ring in (15) as well as the pyrimidine thione in (7) are responsible for their reactivity, rather than the presence of the pyrazoline ring system as in (4a) .On the other hand ,some of the synthesized compounds were tested as for their cytotoxic activity and the results were encouraging . All the synthesized compounds were characterized by elemental analysis as well as spectral data such as IR, 1H-NMR and Mass spectra.


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