Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Synthesis, spectral analysis, antimicrobial evaluation and molecular docking studies of some novel 3,5-dichloro-2,6-diarylpiperidin-4-ones

Author(s): D. Bhakiaraj, T. Elavarasan, M. Gopalakrishnan

A new series of compounds namely, 3,5-Dichloro-2,6-diarylpiperidin-4-ones(11-17) has been synthesized and characterized using various spectral analysis (IR, 1HNMR,13CNMR&Mass). In addition, the title compounds were screened for their antimicrobial activities against a spectrum of clinically isolated microbial organisms. Compoundswith fluoro, chloro, methoxy or methyl functions at the para position of the phenyl rings attached to C-2 and C-6 carbons of the piperidone moiety along with the chlorosubstituents at C-3 and C-5positions of the piperidone ring exerted potent biological activities against antimicrobial strains at a minimum inhibitory concentration. The molecular docking studies have widened the scope of developing a new class of antimicrobial agents.


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