Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Synthesis, spectral analysis, antimicrobial evaluation and molecular docking studies of some novel 3,5-dichloro-2,6-diarylpiperidin-4-ones

Author(s): D. Bhakiaraj, T. Elavarasan, M. Gopalakrishnan

A new series of compounds namely, 3,5-Dichloro-2,6-diarylpiperidin-4-ones(11-17) has been synthesized and characterized using various spectral analysis (IR, 1HNMR,13CNMR&Mass). In addition, the title compounds were screened for their antimicrobial activities against a spectrum of clinically isolated microbial organisms. Compoundswith fluoro, chloro, methoxy or methyl functions at the para position of the phenyl rings attached to C-2 and C-6 carbons of the piperidone moiety along with the chlorosubstituents at C-3 and C-5positions of the piperidone ring exerted potent biological activities against antimicrobial strains at a minimum inhibitory concentration. The molecular docking studies have widened the scope of developing a new class of antimicrobial agents.


PDF

FIND ARTICLES
SCImago Journal & Country Rank
Recommended Conferences
bornova escort karşıyaka escort osmangazi escort buca escort anne porno fetiş porno anal porno bartın escort burdur escort eskişehir escort escort izmir bursa escort porno escort bayan