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Synthesis, spectral characterization and antimicrobial evaluation of novel ├?┬▒- aminophosphonates | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis, spectral characterization and antimicrobial evaluation of novel ├?┬▒- aminophosphonates

Author(s): Sampath Chinnam, Chandrakala Potturi, Suresh Maddila, Vijaya Bhaskara Reddy Muttana, Anjaneyulu Ediga and Venkateswarlu Chinnam

A facile method has been developed for the synthesis of novel α-aminophosphonates 5a-j by the one-pot three component reaction of equimolar quantities of 4-amino-N-2-thiazolyl-benzenesulfonamide (Sulfathiazole) (1), dimethyl phosphite (2) and various aldehydes (4a-j) in dry toluene at reflux conditions via Kabachinik-Fields reaction in high yields (70-80%) without use of any catalyst. Their chemical structures were established by IR, 1H, 13C, 31P-NMR, mass spectral studies and elemental analyses. All the title compounds exhibited promising antibacterial and antifungal activities.


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