Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Synthesis, Spectral Characterization and Biological Studies of Ethyl-4-(biphenyl-2-yl)-2-oxo-6-arylcyclohex-3-ene Carboxylates

Author(s): M.R. Ezhilarasi, R. Mahalakshmi, B. Prabha, C. Raja

A new novel series Ethyl-4-(biphenyl-2-yl)-2-oxo-6-arylcyclohex-3-ene carboxylates are constructed by the reaction of ethylacetoacetate with biphenyl chalcones compounds under four step Michal addition reaction and ethanol used as a solvent and the chalcones synthesized by common Claisen-Schmidt condensation method. The reactions were monitored by Thin layer Chromatography (TLC). The characterization of the synthesized compounds by Infra-Red (IR), Proton Nuclear Magnetic Resonance (1H-NMR), Carbon-13 Nuclear Magnetic Resonance (13CNMR), Correlation Spectroscopy (COSY), Heteronuclear Single Quantum Coherence (HSQC) and Mass spectral data’s and elemental analysis. The synthesized compounds treated against Gram-positive and Gram-negative bacterial strains, the electron with-drawing group’s particularly substituted derivatives (F) group shows greater inhibition against Gram-negative bacterial strain Escherichia coli and the electron donating (OCH3) substitution derivative has shown excellent inhibition against Gram-positive bacterial strain Staphylococcus aureus using ciprofloxacin as a standard drug.