Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Synthesis, spectral characterization, in vitro biological, antioxidant studies of 2,9,16,23- tetra-N-[4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl]benzamido- metallophthalocyanines

Author(s): B. Chidananda, K. R. Venugopala Reddy, M. N. K. Harish, K. M. Pradeepa, C. D. Mruthyunjayacharia, S. D. Ganesh and T. R. Prashith Kekuda

This work reports on the synthesis of tetraamidophthalocyanine (5-7). The structure of tetraamidophthalocyanines was elucidated by FT-IR, 1H NMR, UV-visible spectroscope and elemental analysis. General trends were described for the antimicrobial activity of synthesized metallophthalocyanines screened against a wide range of Gram-positive and Gram-negative bacteria showed modest zone of inhibition, MIC with standard drug was investigated in dimethylsulphoxide (DMSO) and antioxidant with standard ascorbic acid. The results of antimicrobial activity and antioxidant experiments reveal that compound (5-7) exhibit modest activity. All phthalocyanine complexes exhibited excellent solubility in organic solvents such as methanol, ethanol, dimethylformamide and dimethyl sulfoxide.


PDF