Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Synthesis, spectral characterization, thermal, DNA cleavage and in-vitro antimicrobial activity studies of Co(II), Ni(II) and Cu(II) metal complexes of 1, 2, 4-triazole Schiff bases

Author(s): Shivakumar S. Toragalmath, Sangamesh A. Patil , Shrishila N. Unki, Bhimashankar M. Halasangi and Prema S. Badami

A new series of Co (II), Ni (II) and Cu (II) metal complexes with biologically active Schiff bases derived from 3- substituted-4-amino-5-mercapto-1,2,4-triazole and 2-Chloro-3-formylquinoline have been synthesized. The synthesized Schiff bases and their metal complexes have been characterized in the light of elemental analyses, spectral data (IR,1H-NMR, 13C-NMR, ESR and ESI-Mass) Magnetic and thermal studies. The stoichiometry of all the metal complexes is found to be 1:2 of the type ML2.2H2O. The measured molar conductance values in DMSO indicate that, the complexes are non-electrolytic in nature. It has been concluded that, all the metal complexes possess octahedral geometry in which ligand is coordinated to metal ion through azomethine nitrogen and thione sulfur atoms via deprotonation. The Schiff bases and their metal complexes have been screened for their in vitro antibacterial (Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa) and antifungal activities (Aspergillus niger, Penicillium chrysogenum and Candida albicans) by Minimum Inhibition Concentration(MIC) Method. The DNA Cleavage activity is studied by agarose gel electrophoresis method


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