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Synthesis, Spectral, Theoretical, Antimicrobial Evaluation, and Molecular Docking Studies of Some Novel Ethyl 5-(1-Methyl-1h-Tetrazol-5-Ylthio)-4-Oxo-2,6-Substituted Diphenylpiperidine-3-Carboxylate Derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis, Spectral, Theoretical, Antimicrobial Evaluation, and Molecular Docking Studies of Some Novel Ethyl 5-(1-Methyl-1h-Tetrazol-5-Ylthio)-4-Oxo-2,6-Substituted Diphenylpiperidine-3-Carboxylate Derivatives

Author(s): Srikanth R, Venkatesan CS, Sugumar P, Sivarajan A, Ponnuswamy MN

A new series of heterocyclic compounds containing both N-methyl thiotetrazole (NMTT) and piperidine nuclei together, namely ethyl 5-(1-methyl-1H-tetrazol-5-ylthio)-4-oxo-2,6-substituted diphenylpiperidine-3-caboxylate derivatives, were synthesized by cyclocondensation of ethyl 4-(1-methyl-1H-tetrazol-5-ylthio)-3-oxobutanoate with ammonium acetate and substituted aromatic aldehydes. The synthesized N-methylthio tetrazole substituted piperidine-4-one derivatives were evaluated for their antimicrobial activity using disc diffusion method. The structures of the synthesized compounds were characterized by Infrared Radiation (IR), Proton Nuclear Magnetic Resonance (1H-NMR), Carbon-13 (C13) Nuclear Magnetic Resonance (13C-NMR), 2D-NMR and mass spectral data. The antimicrobial activity reveals that several compounds exhibit good antibacterial activity when compared with the reference drug. Molecular docking studies were performed against malarial activities.


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