Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Synthesis, spectroscopic characterization and antimicrobial activity of 5- arylidene-2-substituted-1,3-thiazol-4-one

Author(s): Prajwal L. Lobo, Boja Poojary, D. Jagadeesh prasad, Nalilu Suchetha Kumari

Various substituted 5-arylidene-2-substituted-1,3-thiazol-4-one derivatives 3a-h were synthesized in good yield by the reaction of methyl thiocyanatoacetate 1 with various secondary amines to afford 2-substituted 1,3-thiazol- 4(5H)-one which on further reaction with various aryl aldehydes afforded the title compounds 3a-h. All structures of the newly synthesized compounds were elucidated by elemental analyses, spectral data and a few by single crystal XRD study and screened for their antimicrobial activity.


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