Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Synthesis, Study of Substituent Effect and Evaluation of Biological Activities of (E)-3-phenyl-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-ones

Author(s): Kamalakkannan D, Vanangamudi G, Thirunarayanan G

In the present study, nine number of different substituted (E)-3-phenyl-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one compounds were synthesized by the condensation reaction of 3,4,5-trimethoxy acetophenone with different substituted benzaldehyde in alcoholic base (sodium hydroxide in ethanol). The yields of the products have been obtained above 80%. The formations of all the (E)-3-phenyl-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-ones have been confirmed by analytical and spectroscopic data. All the assigned spectral values of substituted (E)-3-phenyl-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one compounds are correlated by single and multi-correlation analyses with Hammett sigma constants and F & R parameters. From the regression analyses result, the electronic effects of the substituent were discussed. The evaluation of antimicrobial activity of synthesized chalcones has been screened using Kirby-Bauer method.


PDF

FIND ARTICLES
SCImago Journal & Country Rank
Recommended Conferences
bornova escort karşıyaka escort osmangazi escort buca escort anne porno fetiş porno anal porno bartın escort burdur escort eskişehir escort escort izmir bursa escort porno escort bayan