Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Synthesis, swelling behaviour, salt- and pH- sensitivity of crosslinked gellan gum-graft-poly (acrylamide-co-itaconic acid) hydrogels

Author(s): Karthika J. S. and Vishalakshi B.

A new hydrogel of Gellan gum grafted Poly(acrylamide-co-itaconic acid) has been made through chemical crosslinking by graft copolymerization of acrylamide (AAm) and itaconic acid (IA) on to Gellan gum (GG) via free radical polymerization in presence of N, N’-methylene-bis-acrylamide (MBA) as crosslinking agent. Characterization of the gel has been made using FT-IR, TGA and SEM techniques. The influence of preparation conditions, pH and ionic strength on the swelling behaviour of the gels has been investigated. The results revealed that synthesized gels exhibit a reasonable sensitivity to pH and ionic strength.


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