Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Synthetic and Structural Studies of Fe (II) and Zn (II) Complexes of 2'-Hydroxy Chalcones Derived from Pyridine-2-carboxaldehyde, Pyrrole-2-carboxaldehyde

Author(s): Seema I Habib

Complexes of Fe (II) and Zn (II) with 1-(2′-hydroxy-3′-iodo-5′-chlorophenyl)-3-pyridine-2-propen-1-one (L3) and 1-(2′-hydroxy-3′-bromo-5′-chlorophenyl)-3-pyrrole-2-propen-1-one (L5), have been prepared and characterized with the help of elemental analysis, molar conductivity, magnetic measurement, electronic spectra and thermal analysis. Elemental analysis confirmed 1:2 (metal: ligand) stoichiometry. The conductivity data show that all these complexes are non-electrolytic in nature. The infra-red spectral data indicate that the L3 and L5 act as mononegative bidentateligands with the Fe (II) complexes have octahedral geometry whereas the Zn (II) complexes have square planar geometry. Presence of coordinated water molecule in the Fe (II) complexes is confirmed by Thermogravimetric Analysis (TGA) studies. In vitro antimicrobial activities of all synthesized compounds have been evaluated against four bacterial strains and four fungal strains. The compounds show net enhancement in activity on coordination of metals with ligand.