This study was carried out to investigate the effect of passion flower extract and fluoxetine on depression symptoms in mice by using forced swimming test. In this experimental study, forty mature mice from Balb/C race were randomly divided into five groups: Control, fluoxetine and 50, 100 and 200 mg/kg doses of extract. The extract was injected intraperitoneally. Depression was enforced using tetrabenazine 65 minutes before injection. Three groups has been received 50, 100 and 200 mg/ kg hydro alcoholic extract of passion flower via intraperitoneal injection. Group four has been received 1.4 mg/ kg fluoxetine, while group five as a control ones received no treatment.The forced swimming test was used to assess depression mood, and increase in the movement time to second and decrease of time to move less assigned as an index for depression. The SPSS software was used for analyzing collected data. Compare to control group and fluoxetine, hydro alcoholic extract of passion flower with concentration of 50 and 200 mg/kg of mice weight has been significantly increased time of movement and decreased time of move less in samples; and these all shows depression mood. According to results, passion flower hydro alcoholic extract in 50 and 200 mg/kg could reduce the depression and acted like fluoxetine. Therefore, it is recommended as a replacement for fluoxetine.
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