The construction and performance characteristics of PVC electrodes for oxomemazine hydrochloride (OXCl) are described. Different methods for electrodefabrication (modified with the ion-pair, ion pairing agent or soaking the plain electrode in the ion-pair suspension) have been used. Matrix compositions were optimized on the basis of effects of type and content of the modifier as well as influence of the plasticizers. The fabricated electrodes worked satisfactorily in the concentration range from 1×10-6 to 0.001 M with Nernstian cationic slopes, depending on the method of electrode fabrication. The ion-pair modified electrode showed the best performance (slope 59.7 ± 2.1 mVdecade-1) compared with the plain electrodes or modified with sodium tetraphenylborate (NaTPB) and fast response time of about 15 s and adequate lifetime (6 weeks).The developed electrodes have been successfully applied as end point indicator electrode for the potentiometric titration of OXCl with high accuracy and precision.