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The effect of hydro alcoholic extract of garden sag e on liver enzymes in mice under heat stress | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

The effect of hydro alcoholic extract of garden sag e on liver enzymes in mice under heat stress

Author(s): Sayedahmad Sayedain and Mehrdad Modaresi *

Using pharmaceutical plants in reducing stress can play key role in preventing damages of heat stress. The goal of this study was investigating the anti-stress effect s of garden sage (Salvia officinalis)in mice. Fifty mature mice were studied in five groups including control, 0, 100, 2 00, and 400 mg/kg weight of body of hydro alcoholic extract in drink water. Mice were under heat stress (36 ± 0.5° C) for four hours a day. At end of period, blo od samples were prepared and liver enzymes AST, ALT, and ALP were s tudied. According to results, ALP was decreased in zero groupswhereas100 mg/kg compensated the reduction (p < 0.05). AST amount was not different in treatment groups. The amount of ALT was decreased in zero group but 2 00 and 400 mg/kg doses compensated the reduction (p < 0.05). On the whole, hydro alcoholic extract of gar den sage could reduce negative effects of heat stre ss on liver enzymes does dependently.


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