Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

The Protective Effects of Aqueous Extract of Glycyrrhiza Glabra Root Against Hepatic Dysfunction Induced by Thioacetamide in Male Rats

Author(s): Davood Moghadamnia, Mokhtar Mokhtari and Saeed Khatamsaz

Thioacetamide is a liver toxin that causes centrilobular necrosis. In this study, the protective effect of aqueous extract of Glycyrrhiza glabra root against hepatic dysfunction induced by thioacetamide in male rats was investigated.35 male rats were divided into 5 groups of 7 : control group; sham group: receiving a single dose of 150mg/kg thioacetamide intraperitoneally; experimental groups 1 and 2 and 3: they received the aqueous extract of Glycyrrhiza glabra root at the doses of 100,200,300mg/kg daily orally during 3 months respectively and then a single dose of thioacetamide at 150 mg/kg as intraperitoneal injection . The serum levels of SGOT, SGPT, ALP, GGT and LDH were measured. The mean levels of SGPT in the experimental groups 3 and 2 (194.50 ± 13.50) and (222.50± 10.37) showed a significant decrease compared to the group receiving thioacetamide (361± 10.01).The average concentrations of GGT in the experimental groups 3 and 2 (2.50±0.22) and (2.28 ± 0.28) compared to the group receiving thioacetamide (4.50± 0.28) significantly reduced.The mean levels of ALP, LDH and SGOT in all experimental groups did not show significant changes compared to the group receiving thioacetamide (P≤.05).The results of this study showed that the aqueous extract of Glycyrrhiza glabra root had protective effects against the hepatic dysfunction induced by thioacetamide in male rats.


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