Scientists affirmed Helicobacter pylori as strict cause of cancer in humans and type I carcinogen. According to the reports, H. pylori infection occurs in more than half of the world population. Generally H.pylori is accountable for nearby 75% of the entire gastric cancers and 63.4% of the entire stomach cancers over the world. Given the importance of this bacterium and emergence of drug resistant strains need to appropriate vaccine forer abdication of pathogenic strains is felt. The role of UreB, HspA, FlaA, FlaB, CagA, VacA, HpaA as candidate vaccine has been established. For bacterial proteins act as a candidate vaccine antigen, it should preferably be conserved, immunogenic, secreted or surface localized. HpaA protein has all these criteria. According to the conducted studies HpaA protein is a good candidate in the development of vaccines against H. pylori infection, but this factor for inducing appropriate immune responses should be used in combination with the other factors that participating in pathogenesis of infection.