Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

The use of purple sweet potato (Ipomoea batatas) starch as binder in mangosteen peel extracts lozenges formulation

Author(s): Akmal Djamaan, Deni Noviza, Dina Septianingsih and Muslim Suardi

This study was performed to find an alternative ingredient for use as a binder in mangosteen peel extracts lozenges dosage form. The purple sweet potato starch was produced by the decantation method, while mangosteen peel extract was extracted by maceration. The starch was used to formulate the lozenges at three levels of 5, 10, and 15%, and manufactured by wet granulation method. Alpha-mangostin was analyzed by Thin Layer Chromatography Densitometry method. Lozenges were evaluated in term of weight, hardness, brittleness, time dissolves and nutritious substance assay. Results showed that mangosteen peel extract could be formulated in a lozenges dosage forms using purple sweet potato starch as a binder. All of formulas were fullfill the requirements except taste test response. The hardness and time dissolves of Formula III using 15% purple sweet potato starch were 9,4±0,1721 kg/cm2 and 7,092±1,352 minutes, respectively. Formula III was stated as the best formulation.


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