Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Theoretical study by molecular modeling methods the inhibition of acetylcholinesterase

Author(s): I. Abdelli , Mohammad A. Kamal , I. Daoud , S. Ghalem and M. Merad

Alzheimer's disease (AD) is turning out to be one o f the lethal diseases in older people. The etiology is multifactorial, and pathophysiology of the disease is complex. Data indicate an exponential rise in the number of case s of AD, emphasizing the need for developing an effective tr eatment. AD also imposes tremendous emotional and f inancial burden to the patient's family and community. The d isease has been studied over a century, but acetylc holinesterase inhibitors is one drugs currently approved for it m anagement. The multitarget approach is based on the unique structural properties of acetylcholinesterase and t he interaction of the enzyme with the inhibitors; w hich could hold the key to treatment of AD in the near future. Posi phen is an experimental AD drug and it lacks acetyl cholinesterase inhibitory activity. Where the objective of this work consists to use th e molecular modeling methods as theoretical approach to study the inhibition of acetylcholinest erase.


PDF

FIND ARTICLES
SCImago Journal & Country Rank
Recommended Conferences
bornova escort karşıyaka escort osmangazi escort buca escort anne porno fetiş porno anal porno bartın escort burdur escort eskişehir escort escort izmir bursa escort porno escort bayan