Chemical properties of 1,3,4-thiadiazole have been reviewed in last fast five year. However, usefulness of 1,3,4-thiadiazole has a privileged system in the medicinal has been promoted advance on therapeutic potential of the system. This review provides a brief summary of medicinal chemistry of 1,3,4-thiadiazole system. The highlight some example of 1,3,4- thiadiazole containing the drug substance in the current literature. Several five membered aromatic systems having a three heteroatom at symmetrical position such as thiadiazole owing a several pharmacological activity. It covers the most active thiadiazole derivative and structural activity relationship of the most potent compounds. It acts as an important tool for medicinal chemist to develop a newer compound possessing the thiadiazole moiety that could be better agents in term of efficiency and safety.