Abstract

Tremendous effect of Salsola tetrandra and Salsola baryosma on a liver toxicity using paracetamol overdose

Author(s): Ahlam H. Mahmoud, Mahmoud S. Soliman, Nadia S. Metwally, Abdel-Razik H. Farrag, Fatma S. Elsharabasy, Sherifa Arafa and Amr M. M. Ibrahim

The study was conducted to compare the defensive role of Salsola tetrandra and Salsola baryosma plant extracts against paracetamol-instigated intense hepatorenal toxicity in rats. Toxicity was stimulated by administration of a single oral dose of paracetamol (3 g/kg body weight). The extract of the aerial parts of plants (100 mg/kg) was utilized on a pre-and post-treatment basis. Both extracts significantly ameliorate liver and kidney functions with the prophylactic (pre) or therapeutic (post) treatments. Other biochemical markers as malondialdehyde (MDA) content, serum paraoxonase-1(POX-1) enzyme activity interleukin-1(IL-1β) and tumor necrosis factor alpha (TNF-α) level were also reduced. Histopathological and histochemical studies showed parallel effects with the biochemical measured. Both extracts seem to have a plethora of antioxidative compounds with marked effect against paracetamol-induced hepatorenal toxicity in rats. Salsola tetrandra was more potent than S. baryosma on the basis of all measured parameters.

PDF

30+ Million Readerbase

Google Scholar citation report

Citations : 25868

Der Pharma Chemica received 25868 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons