Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Ultrasonic assisted synthesis of novel anticancer chalcones using water as green solvent

Author(s): Ahmed Younis, Usama Fathy, A. Atef El-kate and Hanem M. Awad

The reaction of compound (2) with different aldehydes catalyzed by pulverized NaOH under both ultrasound irradiation using water as green solvent and conventional conditions to afford novel chalcones. It is obvious that the yields and reactions times were improved under ultrasonic irradiation rather than conventional method. All structures were characterized by elemental analysis and spectral data. The synthesized chalcones are evaluated against HepG-2, HCT-116, MCF-7 and Caco-2. Most of compounds showed significant antitumor activities.


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