Ultrasound mediated synthesis of some pyrazoline derivatives using biocompatible deep eutectic solvent (DES) | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Ultrasound mediated synthesis of some pyrazoline derivatives using biocompatible deep eutectic solvent (DES)

Author(s): Mohammed Afroz Bakht

In this report an attempt was made to synthesize so me pyrazoline derivatives by benzalkonium chloride and urea based deep eutectic (DES) solvent using thermal(NUS ) and ultrasonic (US) methods. Similar reaction was tested by conventional solvent (glacial acetic acid) by therm al method. Result obtained in all of the approaches was calculated and compared with regard to the reaction time, temperature and % yield in both of the metho ds considering the glacial acetic acid and DES as solv ent. Reaction took 15 hr to complete when conventio nal solvent(glacial acetic acid) were used by thermal m ethod, but same reaction finishes in 4hr in thermal and 1hr in ultrasonic method using DES as solvent. Ultrasound assisted synthesis along with DES works under room temperature (RT) irrespective of thermal method whe re products are formed at much elevated temperature (<80 0 C). Similarly, rise in %yield was observed in DES led r eaction either in thermal or ultrasonic method. Int erestingly, in DES-ultrasound combined reaction the % yield was as much as 88%. Furthermore, cost effective, recyclab le, environmental friendly nature of DES together with ultrasound make ideal for the present research.


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