Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Uncatalyzed three component synthesis and anti-microbial activity of α-amino phosphonates

Author(s): K. Uma Maheswara Rao, G. Rama Devi, N. Jagannadha Reddy, P. Santhipriya, C. Suresh Reddy

A series of new α-amino phosphonates have been synthesised via one-pot reaction by reacting 2- hydroxy aniline with aromatic aldehydes and dimethyl phosphite in dry toluene under reflux conditions in the absence of catalyst. All the newly synthesized α-amino phosphonates (4a-j) were established by elemental analysis, IR, 1H, 13C, 31P NMR spectroscopy and Mass spectrometry. They were found to possess significant anti-microbial activity.


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